Of course, the ensuing extra point was blocked and returned to cut the 49ers' lead to 14 points.
You can watch Johnson's interception and return for the score below.
The 49ers entered Sunday's matchup with the Jaguars having won three-straight games and four of their last five. Jacksonville was a four-point favorite entering the game.
More San Francisco 49ers News
-
49ers vs. Bills in Week 13: How to watch, stream, and listen, plus odds
The San Francisco 49ers hit the road for the second consecutive week to face the Buffalo Bills on Sunday Night Football at Highmark Stadium. This matchup marks the 14th all-time meeting between the two teams and the first since the 2020 season. San Francisco aims to improve to... -
Schefter comments on Kyle Shanahan's and John Lynch's futures with 49ers
The San Francisco 49ers endured another disheartening loss Sunday night, falling to the Buffalo Bills and dropping to 5-7 on the season. With their playoff hopes dwindling, questions are mounting about the direction of the team and the job security of head coach Kyle Shanahan... -
49ers' Trent Williams and wife mourn the loss of twins
San Francisco 49ers offensive lineman Trent Williams was sidelined Sunday against the Buffalo Bills due to an ankle injury. However, few knew the All-Pro tackle has been facing an unimaginable personal tragedy off the field. Williams and his wife, Sondra, recently experienced... -
49ers practice and media schedule: Preparing for the Week 14 matchup vs. Bears
The San Francisco 49ers will hold three full practices this week as they prepare for their Week 14 matchup against the Chicago Bears. Head coach Kyle Shanahan, defensive coordinator Nick Sorensen, offensive line/run game coordinator Chris Foerster, and quarterback Brock Purdy...