The San Francisco 49ers are preparing for their Week 4 contest against the Los Angeles Chargers on Sunday at the StubHub Center in Carson, California.

Running back Matt Breida's 274 rushing yards this season ties him with Dallas Cowboys running back Ezekiel Elliot for the most in the league. Breida briefly left Sunday's game against the Kansas City Chiefs with a hyperextended knee and calf soreness but was able to return. He was limited during practice on Wednesday and head coach Kyle Shanahan predicted earlier this week that the NFL rushing co-leader would likely be questionable for this weekend's game.


Other injury notes from Wednesday:


Below are Wednesday's practice participation reports for both the 49ers and Chargers, which were provided by the 49ers Communications staff.


San Francisco 49ers Wednesday Practice


Did Not Participate In Practice
S Adrian Colbert (hip), G Joshua Garnett (toe), G Mike Person (knee), CB Richard Sherman (calf), T Joe Staley (not injury related), S Jaquiski Tartt (shoulder)

Limited Participation in Practice
RB Matt Breida (knee), WR Marquise Goodwin (quadricep)

Full Participation in Practice
CB Ahkello Witherspoon (ankle, hip)

Los Angeles Chargers Wednesday Practice


Did Not Participate In Practice
WR Keenan Allen (knee), T Joe Barksdale (knee), DE Joey Bosa (foot)

Limited Participation in Practice
WR Travis Benjamin (foot)


Full Participation in Practice
T Russell Okung (knee), RB Derek Watt (thumb)

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