Bosa is returning from an ankle injury that forced the pass rusher to miss most of training camp and the entire preseason.
Also expected to play are Buccaneers wide receiver Mike Evans and linebacker Devin White, according to Adam Schefter of ESPN. Both were dealing with the flu leading up to the game.
The 49ers and Buccaneers kick off at 1:25 p.m. PT (4:25 p.m. ET) from Raymond James Stadium.
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