Bosa finished the game with four combined tackles, two sacks, five quarterback hits, a forced fumble, and a fumble recovery during the 31-3 victory.
The other award nominees are Jacksonville Jaguars quarterback Gardner Minshew, Arizona Cardinals quarterback Kyler Murray, Oakland Raiders running back Josh Jacobs, and Carolina Panthers linebacker Brian Burns.
Bosa does have the advantage of being the only nominated player who played during primetime.
Fans can click here to vote for the 49ers rookie through Friday. Bosa played college football at Ohio State, and the 49ers made him the No. 2 overall pick in April.
Wide receiver Deebo Samuel was the last 49ers player to be nominated for the award, which occurred after Week 2. He did not end up winning.
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