Defensive end Dee Ford left the game with a hamstring strain and did not return. There is a possibility that the injury could be a multi-week concern.
"Any time you have a hamstring strain, there is concern it could be a couple of weeks," Shanahan told reporters.
Shanahan didn't rule out the possibility that the 49ers might make a move to help fill in during Ford's potential absence, but the team is more likely to turn to someone already in the building.
"We've got guys who can play inside, guys who can play outside, but it's one of the guys that you guys have seen already," Shanahan said.
George Kittle missed his second consecutive game after sustaining knee and ankle injuries during the 49ers' and Cardinals' first matchup in Week 9. The Pro Bowl tight end — and quarterback Jimmy Garoppolo's favorite target — is in a situation comparable to previous weeks. Still, Shanahan has hope for Kittle's availability on Sunday night against the Green Bay Packers.
The coach didn't want to share too much about Kittle's injury, though.
"I know it was enough to keep most people out some time, which it has for George," Shanahan explained. "He's missed two games now, and I know it will go down to the wire again this week, but I'm holding out hope that this week will be different."
Then you have the potential return of Jalen Hurd (back) off of injured reserve, of which Shanahan isn't optimistic. The rookie wide receiver is unlikely to play in a regular-season game this year.
"I don't know if we've 100 percent ended [the possibility of getting him back], but it has not been looking good, so that's kind of out of sight, out of mind for me right now," Shanahan said. "We might have more of an answer on that later in this week just to finalize that. I don't think we have officially yet."
Shanahan did sound more optimistic about the potential returns of cornerback Jason Verrett and defensive end Kentavius Street, both of whom are also on injured reserve. Of course, their return would be dependent on roster needs.
"Those are guys that are working their hardest to get back," Shanahan said. "If we definitely had an injury at a certain spot, we would probably make that decision sooner than later. But they're guys, regardless, even if those injuries don't happen, they're guys who we want to get back out there practicing. Guys that have worked to get back, and we think will be healthy enough to, and we'll see if need be because of injuries. But if not, I'd like to give them a chance to at least get back out on the practice field."
Wide receiver Deebo Samuel (shoulder) and cornerback K'Waun Williams (stinger) left Sunday's game but returned. Shanahan says Williams should be fine, but the team will see how Samuel is feeling this week.
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