The 49ers announced that Jones sustained an ankle injury and is "questionable" to return.
Jones, a sixth-round draft pick out of Ole Miss in 2017, is in his third NFL season. He entered the game with 20 tackles and two sacks through nine games.
Safety Jaquiski Tartt exited the game with a rib injury earlier in the third quarter and was also labeled as "questionable" to return.
San Francisco and Baltimore are currently tied 17-17 in the fourth quarter.
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