Running back Matt Breida (ankle), defensive end Dee Ford (quadricep, hamstring), and tackle Joe Staley (finger) were inactive for the 20-17 loss. Shanahan is hopeful that all three will be healthy enough to play during Week 14.
"I'm holding out hope on all of them," Shanahan told reporters via a conference call on Monday. "I'm definitely more optimistic about Breida, Ford, and Staley. I'd be surprised to get Pettis back.
"None of them are for sure, though, but hopefully we'll be able to get three of the four."
In other 49ers injury news, Shanahan said cornerback Richard Sherman (ankle sprain), safety Jaquiski Tartt (rib fracture), and defensive tackle D.J. Jones (ankle sprain) are day-to-day and will be re-evaluated on Wednesday.
Defensive end Jullian Taylor will be out longer — at least a couple of weeks — with a "ligament issue" in his elbow, said Shanahan.
More San Francisco 49ers News
-
Insider: Brandon Staley unlikely to return to the 49ers
Former Los Angeles Chargers head coach Brandon Staley was considered for the San Francisco 49ers' defensive coordinator role last year but ultimately lost out to Nick Sorensen. Sorensen's tenure was short-lived, as he was dismissed after just one season. When the vacancy... -
NFL insider: 'Keep an eye' on 49ers as suitor for QB Joe Flacco
Veteran quarterback Joe Flacco intends to play in 2025, marking his 18th NFL season. The 40-year-old signal-caller spent his first 11 seasons with the Baltimore Ravens, who selected him in the first round of the 2008 NFL Draft. Since then, Flacco has played for the Denver... -
Star player's wife 'a tad salty' about 49ers missing the playoffs
Kristin Juszczyk had different plans for January. She expected to spend the month watching football—but not from her couch. Instead, she anticipated cheering on her husband, San Francisco 49ers fullback Kyle Juszczyk, from NFL stadiums as the team made another postseason... -
PFF names 49ers' breakout candidate for 2025
Pro Football Focus contributor Bradley Locker recently identified one breakout candidate for every NFL team heading into 2025. The pick for the San Francisco 49ers was wide receiver Ricky Pearsall, a young player whose 2024 rookie campaign took an unexpected turn. The 49ers...