Jones' injury took place during Sunday's win over the New Orleans Saints. The team is awaiting the results of further testing.
Shanahan didn't sound too optimistic about Jones' status and said the loss could prompt the 49ers to activate defensive lineman Kentavius Street from injured reserve.
"We've got Sheldon (Day), who can do it," Shanahan added, "we've got Solomon (Thomas), who can do it, all the guys on the inside, who can do it, (Arik) Armstead, [DeForest Buckner]."
The other players who will sit out Wednesday's practice are defensive end Dee Ford (hamstring), safety Jaquiski Tartt (ribs), defensive lineman Jullian Taylor (elbow), and cornerback Richard Sherman (hamstring) and K'Waun Williams (concussion).
Related News
More San Francisco 49ers News
-
Vernon Davis: 49ers can win NFC West but may have missed championship window
Despite a 5-5 record, the San Francisco 49ers remain in contention for the NFC West title thanks to a tightly contested division. While currently in last place, they are just one game behind the first-place Arizona Cardinals, who sit at 6-4. Former 49ers tight end Vernon Davis... -
Kyle Shanahan on 49ers' fatal flaw: We have to finish in the 4th quarter
Not long ago, the San Francisco 49ers were considered Super Bowl favorites. As they prepare for Week 12 with challenging road matchups against the Green Bay Packers and Buffalo Bills ahead, those expectations have drastically shifted. However, the division-leading Arizona... -
49ers' Kyle Shanahan says Deommodore Lenoir "has the confidence to guard anybody" and the CB has videos to prove it
San Francisco 49ers cornerback Deommodore Lenoir is a rising star. And this week, the 49ers treated him as such, rewarding Lenoir with a five-year, $92 million extension. The 2021 fifth-round selection will now be paid as one of the league's top cornerbacks, deservedly so. He's... -
Kyle Shanahan reflects on 49ers' Week 11 loss vs. Seahawks, provides injury updates
San Francisco 49ers head coach Kyle Shanahan spoke with reporters during a conference call on Monday, the day after the team's 20-17 loss to the Seattle Seahawks. Here's everything he said. Transcript provided by the San Francisco 49ers Communications staff. Opening...