All 10 participating staff members selected the 49ers to beat the Cardinals. San Francisco is currently a 6.5-point favorite.
As for all the fans who are taking part in our NFL Pick 'em contest, 96 percent have the 49ers winning the game, as of this post.
Of all the Week 1 game predictions, the most lopsided result comes from the matchup between the New York Jets and the Buffalo Bills on Sunday. Voting has 98 percent of fans believing the Bills will earn the victory.
The closest matchup, when it comes to the predictions, is between the Green Bay Packers and the Minnesota Vikings on Sunday, with 58 percent selecting the Vikings to win the game.
There is still time for you to join our NFL Pick 'em contest. Compete all season for prizes and bragging rights.
| Picks | Away | Home | Picks |
|---|---|---|---|
|
7%
|
Texans
|
Chiefs
|
93%
|
|
3%
|
Browns
|
Ravens
|
97%
|
|
89%
|
Colts
|
Jaguars
|
11%
|
|
64%
|
Raiders
|
Panthers
|
36%
|
|
91%
|
Eagles
|
Washington
|
9%
|
|
20%
|
Dolphins
|
Patriots
|
80%
|
|
42%
|
Packers
|
Vikings
|
58%
|
|
30%
|
Bears
|
Lions
|
70%
|
|
2%
|
Jets
|
Bills
|
98%
|
|
61%
|
Seahawks
|
Falcons
|
39%
|
|
67%
|
Chargers
|
Bengals
|
33%
|
|
4%
|
Cardinals
|
49ers
|
96%
|
|
19%
|
Buccaneers
|
Saints
|
81%
|
|
70%
|
Cowboys
|
Rams
|
30%
|
|
91%
|
Steelers
|
Giants
|
9%
|
|
70%
|
Titans
|
Broncos
|
30%
|
More San Francisco 49ers News
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Jets shopping Davante Adams, but a 49ers trade seems unlikely
NFL Network's Ian Rapoport reports that the New York Jets are fielding calls on wide receiver Davante Adams, hoping to offload his massive salary before the new league year begins on March 12. Sources: The #Jets are now taking calls on star WR Davante Adams, open to trading... -
Report: Teams have inquired about trading for 49ers WR Brandon Aiyuk
It seems unlikely that any team would pursue a trade for San Francisco 49ers wide receiver Brandon Aiyuk at this time. Not only is he now among the NFL's highest-paid wideouts, but he is also recovering from a significant ACL injury. No one is even sure Aiyuk will be ready to... -
PFN predicts 49ers will sign Chiefs LB Nick Bolton
With free agency just weeks away, the San Francisco 49ers could be in the market for a linebacker to replace Dre Greenlaw. The fan-favorite defender appeared in only two games last season after returning from an Achilles injury, only to suffer a setback that sidelined him for... -
Former NFL player explains how 49ers could benefit from paying Brock Purdy $54M annually
The Athletic's Dianna Russini and former NFL quarterback Chase Daniel discussed Brock Purdy on the Scoop City podcast, examining what his next contract might look like. The San Francisco 49ers are expected to extend their young quarterback, and many believe he will soon rank...