On Sunday night, San Francisco will face the Rams for the first time this year.
The Green Bay Packers and Buffalo Bills are also listed among the 49ers' toughest remaining opponents, with the Washington Redskins and the Dallas Cowboys as the only two teams listed as the team's easiest upcoming opponents.
Injuries have decimated the 49ers roster. The defensive line has lost Nick Bosa and Solomon Thomas for the season to ACL injuries. Pass rusher Dee Ford remains out indefinitely with a back injury. Veteran cornerback Richard Sherman (calf) has not played since Week 1, and K'Waun Williams recently landed on injured reserve with an ACL sprain.
We learned this week that linebacker Kwon Alexander is out indefinitely with a high-ankle sprain.
On offense, quarterback Jimmy Garoppolo is trying to regain his form after dealing with a high-ankle sprain. After missing two games, he had perhaps the worst game of his career on Sunday when he went 7-of-17 for 77 yards, two interceptions, and a career-low passer rating of 15.7 during two quarters of play.
San Francisco faces a particularly challenging stretch between now and its bye week. In addition to having the Rams and Seahawks on the schedule over the next five weeks, the 49ers will play the New England Patriots, Packers, and New Orleans Saints.
The 49ers are exiting what most considered to be the easier portion of their schedule, own a 2-3 record, sit at the bottom of the NFC West, and remain winless at home.
More San Francisco 49ers News
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49ers practice and media schedule: Preparing for the Week 12 matchup vs. Packers
The San Francisco 49ers will hold three full practices this week as they prepare for their Week 12 matchup against the Green Bay Packers. Head coach Kyle Shanahan, defensive coordinator Nick Sorensen, offensive line/run game coordinator Chris Foerster, and quarterback Brock... -
49ers practice and media schedule: Preparing for the Week 13 matchup vs. Bills
The San Francisco 49ers will hold three full practices this week as they prepare for their Week 13 matchup against the Buffalo Bills. Only two will be accessible by the media due to the Thanksgiving holiday. Head coach Kyle Shanahan and defensive coordinator Nick Sorensen are... -
Pelissero provides update on Brock Purdy's injury and 49ers-Packers status
San Francisco 49ers quarterback Brock Purdy was limited during Wednesday's practice and refrained from throwing altogether in at least the position of practice that was open to the media. Purdy is dealing with a shoulder injury sustained during Sunday's loss to the Seattle... -
49ers vs. Packers injury report: Purdy briefly throws before exiting practice; Still no Williams, Bosa
The San Francisco 49ers are preparing for their Week 12 contest against the Green Bay Packers on Sunday at Lambeau Field in Green Bay, Wisconsin. Brock Purdy, who refrained from throwing during Wednesday's practice due to a shoulder injury, resumed light throwing to team staff...