Wilson sustained the injury while running for his third touchdown of the game midway through the third quarter. Wilson was in visible pain while holding his leg after the play, then was carted off the field after hobbling to the sidelines. He was initially declared questionable to return.
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Wilson, who joined the 49ers in 2018 as an undrafted rookie out of North Texas, was in the starting lineup Sunday with Raheem Mostert on injured reserve with a high ankle sprain. Wilson rushed for 112 yards on 17 carries before departing the game and became the first 49ers running back to score three touchdowns in a road game since Roger Craig in 1988.
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