Hasty suffered a broken collarbone during the fourth quarter of Sunday's 27-13 loss to the New Orleans Saints. Head coach Kyle Shanahan said Hasty will have surgery and is done for the season.
Cyprien suffered a hamstring injury.
San Francisco signed Hasty as an undrafted free agent out of Baylor in April. He started the season on the practice squad but was promoted to the active roster on September 26.
Hasty finished the season with 39 carries for 148 yards with a rushing touchdown while adding seven receptions for 33 yards through six games. He has been active in eight games but did not touch the football during Weeks 4 and 5.
The 49ers remain hopeful that running backs Raheem Mostert (ankle) and Tevin Coleman (knee) will return after the bye week.
San Francisco signed Cyprien on August 20. The veteran appeared in four games this season, recording two tackles and a forced fumble.
The 49ers also placed safety Jared Mayden on the practice squad injured list, which is similar to injured reserve. He suffered a quad injury during Sunday's game after being activated from the practice squad. Shanahan said Mayden is expected to miss a few weeks and might have a chance to return this season.
Related News
More San Francisco 49ers News
-
San Francisco 49ers' 2025 opponents finalized after clinching last-place schedule
The San Francisco 49ers' Week 17 loss to the Detroit Lions officially locked the team into last place in the NFC West, regardless of the outcome of their Week 18 matchup against the Arizona Cardinals. While the season has been disappointing, the silver lining is that the 49ers... -
49ers place Dre Greenlaw on IR, announce O-line signing
The San Francisco 49ers have announced that linebacker Dre Greenlaw has been placed on injured reserve. In a corresponding move, the team has added offensive lineman Zack Johnson to the practice squad. Greenlaw appeared in two games following his recovery from a torn Achilles... -
49ers mailbag: Why did SF abandon the run against Detroit? Will the 49ers focus on offense or defense this offseason? Will SF replace Nick Sorensen with Robert Saleh?
There are a lot of questions that will follow the San Francisco 49ers into the offseason. Who will get extensions? Who will be let go? What moves will they make in free agency and the draft? And many more. You have questions, as well, and that's a good thing because we opened... -
Recap: 49ers end season in humiliating fashion with error-filled 47-24 loss to Cardinals
The 2024 season came to a fitting end for the San Francisco 49ers on Sunday, based on how things went for the team over the last several weeks. Playing without quarterback Brock Purdy and a number of other players due to injury, the short-handed 49ers stayed competitive with...