Of course, the game won't be at Levi's Stadium, as Santa Clara County has banned contact sports in the area due to growing COVID-19 numbers. Instead, the 49ers have found refuge in the desert, and for at least the next couple of weeks, will call State Farm Stadium in Glendale, Arizona home.
The 49ers can increase their playoff chances by going on a run in these final five games of the season. That will mean overcoming the odds once again and knocking off the AFC East-leading Bills.
According to MyBookie, the Bills opened as 2.5-point favorites (O/U 48.5) over the 49ers in the upcoming matchup at State Farm Stadium. Buffalo is coming off a 27-17 home victory over the Los Angeles Chargers.
San Francisco still sits in last place within the NFC West standings, but its win over Los Angeles and an Arizona Cardinals loss in Week 12 closed the gap. The Seattle Seahawks, of course, remain in the top spot at 8-3.
The 49ers and Bills are scheduled to kick off on Monday at 5:15 p.m. PT.
More San Francisco 49ers News
-
'The window is closed': Analyst declares 49ers' era of dominance over
The San Francisco 49ers lost significant talent this offseason, leading many to declare that their Super Bowl window had slammed shut. While the team hopes its 11 draft picks from last week can help restock the roster and spark another run, one ESPN analyst remains... -
49ers climb in power rankings after defense-heavy draft haul
NFL.com's Eric Edholm released his post-draft power rankings, offering insight into where each team stands after adding their latest rookie classes. At the top of the list are the Super Bowl champion Philadelphia Eagles, whose draft haul once again earned Edholm's praise. The... -
49ers Draft Night Vibes at Levi's Stadium
This past Thursday, I had the chance to soak in the electric atmosphere at Levi's Stadium for the 49ers' Draft Party. From the gold-blooded diehards to the next generation of the Faithful, there was plenty of buzz about who the 49ers would select with the 11th overall pick. As... -
John Lynch and Kyle Shanahan discuss the 49ers drafting Mykel Williams; Williams speaks to reporters
San Francisco 49ers general manager John Lynch and head coach Kyle Shanahan spoke to reporters after selecting Georgia defensive end Mykel Williams with the 11th overall pick. Additionally, Williams spoke to reporters via Zoom. Here is everything they said. Transcripts...