As it does every season, San Francisco will play each NFC West opponent twice. The team will also face the entire NFC North and AFC South divisions and this season's last-place opponents from the NFC South and NFC East — the Atlanta Falcons and Philadelphia Eagles.
The NFL is also expected to add a 17th regular-season game to boost revenues and offset the losses caused by the COVID-19 pandemic. Limited or no fans were allowed in NFL venues during this season. As a result, the league is likely to see a drop in team salary caps, and the additional game for each team would help minimize that drop.
It hasn't been revealed how the location of that 17th game will be determined. We know that each NFC West team will be matched up against the AFC North opponent with the same spot in its standings. That would mean the 49ers going up against the last-place Cincinnati Bengals.
Below are the 49ers' matchups for next season, with the division opponents listed first and then the remaining teams in alphabetical order.
Home Opponents
Arizona Cardinals
Los Angeles Rams
Seattle Seahawks
Atlanta Falcons
Green Bay Packers
Houston Texans
Indianapolis Colts
Minnesota Vikings
Road Opponents
Arizona Cardinals
Los Angeles Rams
Seattle Seahawks
Chicago Bears
Detroit Lions
Jacksonville Jaguars
Philadelphia Eagles
Tennessee Titans
Location TBD
Cincinnati Bengals
Related News
More San Francisco 49ers News
-
ESPN 7-round mock draft: 49ers bolster trenches early, add QB and kicker late
With the 2025 NFL Draft just days away, ESPN analyst Jordan Reid has released a full seven-round mock draft, projecting all 257 selections. While the San Francisco 49ers have numerous directions they could go, many expect the team to prioritize the trenches with their first of... -
49ers' glaring need still apparent in early 2026 mock draft
The San Francisco 49ers did not select an offensive tackle during the 2025 NFL Draft—a position many considered one of the team's most significant needs, given Trent Williams' age and the fact that the future Hall of Fame left tackle missed the final seven games of the... -
Lifelong 49ers fan living his dream after being drafted by San Francisco
Not many San Francisco 49ers fans were familiar with Montana wide receiver Junior Bergen, the seventh-round draft pick the team hopes will contribute as a returner on special teams. However, Bergen knows all about the Niners, as he's been a lifelong fan, a fact he shared during... -
49ers climb in power rankings after defense-heavy draft haul
NFL.com's Eric Edholm released his post-draft power rankings, offering insight into where each team stands after adding their latest rookie classes. At the top of the list are the Super Bowl champion Philadelphia Eagles, whose draft haul once again earned Edholm's praise. The...