Tackle Trent Williams, quarterback Trey Lance, and defensive tackle Javon Kinlaw have missed three consecutive practices.
Williams suffered an ankle sprain during the 49ers' Week 5 loss to the Arizona Cardinals. Head coach Kyle Shanahan repeated what he said on Thursday, that the veteran tackle tweaked the injury during Monday's practice. The final decision on Williams will go all the way up to game time, said the coach. For now, he has been ruled "doubtful." Rookie Jaylon Moore will start if Williams doesn't play.
Lance emerged from that Week 5 game with a knee sprain. He has been ruled "out" as he continues to recover.
Kinlaw is dealing with the same knee injury that has plagued him all season. The initial injury occurred last season, on December 20, 2020, against the Dallas Cowboys. Kinlaw has been ruled out and Shanahan said the second-year defender is a candidate to land on injured reserve.
During Thursday's practice, defensive tackle Maurice Hurst suffered an injury and was seen today leaving the 49ers' facility on crutches and wearing an orthopedic boot. Shanahan said Hurst suffered a "pretty bad" calf injury and could miss four to eight weeks.
Shanahan was asked if Jimmy Garoppolo is good to go and will start at quarterback on Sunday.
"Yeah, definitely," Shanahan responded. "He got better each day, and I see him as 100-percent now."
Below are the official injury reports for the 49ers and Colts, which were provided by the 49ers Communications staff. Also included are Friday's practice participation reports.
San Francisco 49ers
Out
DL Maurice Hurst (calf), DT Javon Kinlaw (knee), QB Trey Lance (knee)
Doubtful
T Trent Williams (ankle, elbow)
Questionable
LB Marcell Harris (thumb)
Indianapolis Colts
Out
S Julian Blackmon (Achilles), T Braden Smith (foot, thumb), DE Kemoko Turay (groin), RB Jordan Wilkins (non-football illness), CB Rock Ya-Sin (ankle)
Questionable
WR T.Y. Hilton (quadricep)
San Francisco 49ers Friday Practice
Did Not Participate In Practice
DL Maurice Hurst (calf), DT Javon Kinlaw (knee), QB Trey Lance (knee), T Trent Williams (ankle, elbow)
Limited Participation in Practice
LB Marcell Harris (thumb)
Full Participation in Practice
QB Jimmy Garoppolo (calf), CB K'Waun Williams (calf)
Indianapolis Colts Friday Practice
Did Not Participate In Practice
S Julian Blackmon (Achilles), WR T.Y. Hilton (quadricep), DE Kemoko Turay (groin), RB Jordan Wilkins (non-football illness), CB Rock Ya-Sin (ankle)
Limited Participation in Practice
DE Tyquan Lewis (elbow), T Braden Smith (foot, thumb)
Full Participation in Practice
TE Jack Doyle (not injury related - resting player), LB Darius Leonard (ankle, knee), DE Kwity Paye (hamstring), CB Xavier Rhodes (ankle), S Andrew Sendejo (concussion)
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