All six participating staff members this week selected the 49ers to beat the Jaguars. San Francisco is currently a 6.5-point favorite. The Niners would improve to 5-5 with a win.
As for all the fans who are taking part in our NFL Pick 'em contest, 97 percent have the 49ers winning the game, as of this post.
Of all the Week 11 game predictions, the most lopsided result comes from Monday's matchup between the New York Giants and the Tampa Bay Buccaneers. Voting has 100 percent of fans believing the Buccaneers will earn the victory.
When it comes to the predictions, the closest matchup is between the Cincinnati Bengals and the Las Vegas Raiders on Sunday, with 56 percent selecting the Bengals to win the game.
Below is a breakdown of all 15 matchups for the upcoming slate of NFL games.
Picks | Away | Home | Picks |
---|---|---|---|
97%
|
49ers
|
Jaguars
|
3%
|
18%
|
Washington
|
Panthers
|
82%
|
43%
|
Saints
|
Eagles
|
57%
|
71%
|
Dolphins
|
Jets
|
29%
|
87%
|
Packers
|
Vikings
|
13%
|
1%
|
Texans
|
Titans
|
99%
|
7%
|
Lions
|
Browns
|
93%
|
96%
|
Ravens
|
Bears
|
4%
|
3%
|
Colts
|
Bills
|
97%
|
56%
|
Bengals
|
Raiders
|
44%
|
42%
|
Cowboys
|
Chiefs
|
58%
|
67%
|
Cardinals
|
Seahawks
|
33%
|
10%
|
Steelers
|
Chargers
|
90%
|
0%
|
Giants
|
Buccaneers
|
100%
|
More San Francisco 49ers News
-
Final mock draft roundup: Brugler, Breer, Zierlein, other experts make final 49ers predictions
It's draft day! Several top NFL analysts have released their final mock drafts for the 2025 NFL Draft, offering insight into what the San Francisco 49ers might do with the first of their 11 total picks—the No. 11 overall selection. With several key needs to address, the... -
Lifelong 49ers fan living his dream after being drafted by San Francisco
Not many San Francisco 49ers fans were familiar with Montana wide receiver Junior Bergen, the seventh-round draft pick the team hopes will contribute as a returner on special teams. However, Bergen knows all about the Niners, as he's been a lifelong fan, a fact he shared during... -
Chris Simms: 'I thought the San Francisco 49ers absolutely crushed the draft'
Some "experts" weren't impressed with the San Francisco 49ers' approach in the 2025 NFL Draft. Both Pro Football Focus and Sports Illustrated gave the team a disappointing "D" grade, clearly underwhelmed by the 49ers' 11-player draft haul. But not everyone shared that opinion.... -
Details emerge on George Kittle's contract extension with 49ers
Tight end George Kittle signed a four-year, $76.4 million contract extension with the San Francisco 49ers on Tuesday. Pro Football Talk's Mike Florio shared the specifics of the deal, which once again makes Kittle the highest-paid tight end in the NFL. The new agreement is a...