49ers Inactives:
- RB JaMycal Hasty
- DL Maurice Hurst
- OL Colton McKivitz
- RB Elijah Mitchell
Mitchell, San Francisco's leading rusher, sustained a finger fracture in the team's Week 10 win over the Los Angeles Rams and did not practice this past week.
The Jaguars' leading rusher, James Robinson, is active. On Friday, he was listed as "questionable" due to heel and knee injuries.
On Saturday, the 49ers activated safety Jaquiski Tartt from the injured reserve list, five days after placing safety Tavon Wilson on injured reserve.
The team also activated cornerback Davontae Harris from the practice squad, making him available against the Jaguars.
Jaguars Inactives:
- RB Devine Ozigbo
- CB Tre Herndon
- LB Dakota Allen
- TE Jacob Hollister
- DE/OLB Jordan Smith
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