The 49ers shared the following post from the team's official Twitter account.
Several 49ers players, including quarterback Trey Lance, reacted to the news on social media.
Some former 49ers players were also shocked by the news.
This should make head coach Kyle Shanahan's Friday press conference very interesting. He is scheduled to speak with reporters after the afternoon practice.
A few 49ers beat writers have already weighed in on the story.
Even McCaffrey's alma mater had something to say.
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