The San Francisco 49ers knocked off the Arizona Cardinals 38-10 on Monday night at Estadio Azteca in Mexico City. The team set a new record for wins on Monday Night Football with the victory. San Francisco's 52 wins break a first-place tie with the Pittsburgh Steelers.

Franchises with the most wins on Monday Night Football:

  1. San Francisco 49ers - 52
  2. Pittsburgh Steelers - 51
  3. Dallas Cowboys - 49
  4. Miami Dolphins - 43
  5. Las Vegas Raiders - 42

The 49ers are now 5-1 against the Cardinals on Monday Night Football. In addition, they are now 3-1 in international play.

Monday night's game was a rematch of the inaugural NFL regular season game played in Mexico City on October 2, 2005. The Cardinals won that matchup 31-14.

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