With at least two touchdown passes and a victory at Pittsburgh on Kickoff Weekend (10:00 AM PT, FOX), Purdy will become the first quarterback in NFL history to win each of his first six career regular-season starts and throw at least two touchdown passes in each start.
He can also become the first quarterback in NFL history with a passer rating of 95 or higher in each of his first six career regular-season starts.
Brock Purdy's 2022 regular-season starts:
| Week | Opponent | Result | Pass Yds | Pass TDs | Rating |
| Week 14 | vs. Tampa Bay | W 35-7 | 185 | 2 | 134.0 |
| Week 15 | at Seattle | W 21-13 | 217 | 2 | 117.0 |
| Week 16 | vs. Washington | W 37-20 | 234 | 2 | 114.6 |
| Week 17 | at Las Vegas | W 37-34 (OT) | 284 | 2 | 95.4 |
| Week 18 | vs. Arizona | W 38-13 | 178 | 3 | 141.3 |
Information provided by NFL Communications.
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