McCaffrey led the NFL in scrimmage yards and scrimmage touchdowns in Week 4.
This is the second career Player of the Week award for McCaffrey, who last earned the honor in Week 8 last season. He is the fourth 49ers running back to win the award multiple times, joining Roger Craig (4), Garrison Hearst (3), and Frank Gore (5).
McCaffrey becomes the third former Stanford player to earn Offensive Player of the Week honors multiple times, joining quarterbacks John Elway (15-time winner) and Andrew Luck (5-time winner).
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