During last Sunday's matchup against the Cleveland Browns, McCaffrey and Samuel were forced to exit the game due to injuries. Samuel suffered a shoulder injury in the opening quarter, while McCaffrey sustained an oblique injury in the third.
RELATED

Williams suffered an ankle injury in the first quarter but fought through the pain, staying in the game.
On Friday afternoon, head coach Kyle Shanahan joined Bay Area radio station KNBR for his weekly interview, shedding some light on the statuses of his ailing players. Even though they haven't practiced this week, the coach is keeping the door open for their availability against the Vikings.
"None of them could practice today because of their injuries," Shanahan said on the "Tolbert and Copes" show. "We're not ruling them out for this week. When we say day-to-day, that means we're waiting each day to see how they come in the next morning because they don't have stuff to where they for sure can't play. They have chances to recover here."
One silver lining noted by the coach is the additional day of recovery time thanks to the game being played on Monday night rather than Sunday.
Shanahan added, "They're getting closer, but they haven't been good enough to get out there and practice yet."
You can listen to the entire conversation with Shanahan below.
More San Francisco 49ers News
-
Kyle Shanahan: 49ers set with Christian McCaffrey but open to drafting a RB
The San Francisco 49ers' decision to trade Jordan Mason to the Minnesota Vikings surprised many. Mason led the team in rushing yards last season, stepping up as Christian McCaffrey battled injuries. Moving on from Mason speaks volumes about the team's confidence in Isaac... -
Insider: 49ers open to trading Brandon Aiyuk amid talks with several teams
FOX Sports insider Jordan Schultz weighed in on the ongoing situation between the San Francisco 49ers and wide receiver Brandon Aiyuk. "Sources indicate that the 49ers are open to trading Aiyuk — a terrific player who will certainly be motivated — and there has... -
Kyle Shanahan hopeful Brock Purdy won't miss time amid 49ers contract talks
The San Francisco 49ers are working to finalize a contract extension with quarterback Brock Purdy, aiming to get a deal done sooner rather than later. However, if negotiations stall, they could stretch into the offseason program, raising the question: Would Purdy hold... -
Kyle Shanahan: 49ers will add veteran kicker to compete with Jake Moody
Kicker Jake Moody struggled in his second NFL season, converting just 24 of 34 field goal attempts. His inconsistency likely cost the San Francisco 49ers key victories and frustrated fans. All of Moody's missed field goals came from 40 yards or longer, with most occurring...