All-Pro safety Talanoa Hufanga was carted to the locker room in the third quarter and ruled out with a knee injury. Rookie Ji'Ayir Brown replaced Hufanga.
The 49ers are concerned about Hufanga, with the team fearing an ACL injury, per Shanahan. However, the team must wait until Monday, when the safety will undergo an MRI to determine the severity of the injury.
"We don't know for sure, but most likely it's [an] ACL," Shanahan said. "But we can't confirm it, so we'll find out later."
Hufanga was seen leaving the locker room on crutches and wearing a knee brace.
"My heart goes out to Huf," linebacker Fred Warner said after the game. "Not exactly sure what's going on there, but obviously they're fearing the worst for him right now. And obviously, my heart and prayers go out to Huf. Man, that's sickening news."
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