Below are the official injury status reports for the two teams.
San Francisco 49ers
Out
RB Christian McCaffrey (calf, Achilles)
Doubtful
S Talanoa Hufanga (knee)
Questionable
LB Dee Winters (ankle)
Minnesota Vikings
Out
WR Jordan Addison (ankle)
Questionable
FS Harrison Smith (hip), OT Brian O'Neill (elbow), G Ed Ingram (tricep)
Notes
Running back Christian McCaffrey was limited in practice on Wednesday and Thursday but did not participate in Friday's session. He missed the Week 1 matchup against the New York Jets and has been working to recover from a calf strain and Achilles tendinitis—injuries that sidelined him for most of training camp and the entire preseason.
The 49ers have ruled Christian McCaffrey out for Week 2. Head coach Kyle Shanahan mentioned that the team is now considering placing the running back on injured reserve, which would sideline him for at least four games.
"It's something we're considering now," Shanahan said. "Yeah, yesterday was his worst day. It's on and off, but with yesterday having the most pain, it's something we're going to be discussing here the next 24 hours."
Safety Talanoa Hufanga, defensive end Yetur Gross-Matos, linebacker Dee Winters, and wide receiver Jauan Jennings all participated in the team's final practice of the week.
Below are Friday's practice participation reports for both the 49ers and Vikings, which were provided by the 49ers Communications staff.
San Francisco 49ers Friday Practice
Did Not Participate In Practice
RB Christian McCaffrey (calf, Achilles)
Limited Participation in Practice
S Talanoa Hufanga (knee), LB Dee Winters (ankle)
Full Participation in Practice
G Aaron Banks (finger, calf), DE Yetur Gross-Matos (knee), WR Jauan Jennings (ankle)
Minnesota Vikings Friday Practice
Did Not Participate In Practice
WR Jordan Addison (ankle), CB Stephon Gilmore (not injury related - rest)
Limited Participation in Practice
FS Harrison Smith (hip), OT Brian O'Neill (elbow), G Ed Ingram (tricep)
Full Participation in Practice
C Garrett Bradbury (knee), WR Jalen Nailor (ankle)
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