"It will be at least a month, probably longer," Shanahan stated.
The team is considering placing Hufanga on injured reserve, which would sideline him for at least four games. However, nothing has been decided yet.
In addition, several other players are not expected to practice on Tuesday: linebacker Demetrius Flannigan-Fowles (calf), kicker Jake Moody (ankle), and defensive tackle Jordan Elliott (knee).
The 49ers are uncertain how long it will take for Moody's high-ankle sprain to heal, but Shanahan speculated it could be around a month. Moody is also a candidate for injured reserve.
Cornerback Charvarius Ward will be limited after suffering a knee bruise in Sunday's game. At the same time, tight end George Kittle (ribs), linebacker Fred Warner (ankle), wide receiver Chris Conley (oblique), and safety Ji'Ayir Brown (ankle) are also expected to participate in a limited capacity.
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