The 49ers are already without wide receiver Jauan Jennings, who was ruled out for the game. On Saturday, the team activated rookie wide receiver Ricky Pearsall from the non-football injury (NFI) list. Pearsall is set to make his NFL debut just seven weeks after being shot in the chest during a robbery attempt in San Francisco.
This season, Samuel has recorded 20 catches for 335 yards and a touchdown. He also has 19 carries for 51 rushing yards and one rushing touchdown.
San Francisco is favored by 2.5 points ahead of kickoff.
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