The 49ers activated McCaffrey from injured reserve on Saturday, intending for the star running back to make his 2024 season debut. He has been sidelined with Achilles tendinitis.
Meanwhile, Samuel has been dealing with rib and oblique injuries, limiting his participation in practice throughout the week.
"They've had a good week," Shanahan said of Samuel and wide receiver Jauan Jennings, who has missed the last two games. "I expect them to be back."
The 49ers enter Week 10 with a 4-4 record, aiming to secure their first back-to-back wins of the season.
The other 49ers listed as questionable are defensive end Nick Bosa (hip) and safety Malik Mustapha (calf). Offensively lineman Jon Feliciano (knee) was downgraded and ruled out. He remains on injured reserve.
Related News
More San Francisco 49ers News
-
49ers vs. Seahawks final injury report: Trent Williams, George Kittle, 3 others questionable to play
The San Francisco 49ers are preparing for their Week 18 contest against the Seattle Seahawks on Saturday at Levi's Stadium in Santa Clara, California. Both teams have released their official injury reports, which are provided below. San Francisco 49ers Questionable TE George... -
NFL insider says 49ers QB Brock Purdy's shoulder stinger "not expected to keep him out next week"
The San Francisco 49ers looked bad in their bid for the number-one seed in the NFC Saturday night, falling 13-3 to the Seattle Seahawks. But things almost got much worse when QB Brock Purdy went down late in the game. It looked bad, and there was immediate concern about whether... -
49ers' Brock Purdy sounds confident Trent Williams will play vs. Eagles
The San Francisco 49ers were without future Hall of Fame left tackle Trent Williams in Week 18 against the Seattle Seahawks. Williams suffered a hamstring injury on the first offensive play of the previous game against the Chicago Bears, forcing him to miss most of that contest... -
Who will the 49ers play if they beat the Eagles?
Two NFC Wild Card games are already in the books, with the Los Angeles Rams (defeated the Carolina Panthers) and the Chicago Bears (defeated the Green Bay Packers) advancing to the NFC Divisional Playoff round. If the San Francisco 49ers pull off an upset over the Philadelphia...