The 49ers activated McCaffrey from injured reserve on Saturday, intending for the star running back to make his 2024 season debut. He has been sidelined with Achilles tendinitis.
Meanwhile, Samuel has been dealing with rib and oblique injuries, limiting his participation in practice throughout the week.
"They've had a good week," Shanahan said of Samuel and wide receiver Jauan Jennings, who has missed the last two games. "I expect them to be back."
The 49ers enter Week 10 with a 4-4 record, aiming to secure their first back-to-back wins of the season.
The other 49ers listed as questionable are defensive end Nick Bosa (hip) and safety Malik Mustapha (calf). Offensively lineman Jon Feliciano (knee) was downgraded and ruled out. He remains on injured reserve.
Related News
More San Francisco 49ers News
-
49ers' Trent Williams expected to play vs. Eagles
The San Francisco 49ers are expected to have star left tackle Trent Williams available for Sunday's Wild Card matchup against the Philadelphia Eagles, according to ESPN's Adam Schefter. Williams suffered a hamstring injury early in Week 17's game against the Chicago Bears,... -
Why the Seahawks listed Sam Darnold as questionable for 49ers playoff game
The Seattle Seahawks ruled out just one player for Saturday night's NFC playoff matchup against the San Francisco 49ers—tackle Josh Jones (knee). However, one designation on the injury report drew more attention: quarterback Sam Darnold was listed as questionable due to an... -
49ers rally around George Kittle in playoff win over Eagles: 'We're going to play for him the rest of the way'
The San Francisco 49ers could have let George Kittle's second-quarter injury derail their Wild Card playoff matchup against the Philadelphia Eagles on Sunday. Instead, they rallied around their All-Pro tight end, fought through adversity, and pulled off a 23-19 road upset to... -
Trick play for the ages: Behind the 49ers' wild Jauan Jennings touchdown pass in win over Eagles
Regardless of whether or not the San Francisco 49ers win in the NFC Divisional Round next week against the Seattle Seahawks, it's going to be hard to find a better highlight reel play for the 2025 team than the double reverse touchdown pass from wide receiver Jauan Jennings to...