Earlier in the week, there was optimism that Purdy would be ready for the Week 12 matchup after he reported shoulder soreness to the team on Monday. However, concerns grew as the week progressed, with Purdy struggling to take the field alongside his teammates during practice sessions.
"I don't want to say there's long-term concern," Shanahan said. "We got the MRI on Monday. We thought he just needed some rest and really weren't concerned about him not being good this week. But when he started up Thursday, it just surprised him, surprised us how it felt. So we had to shut him down. So I really don't know what to think of it.
"The MRI doesn't look like that, so it should be all right. But the way it responded this week, it's really up in the air for next week. So, we'll have to see on Monday."
With Purdy out, veteran quarterback Brandon Allen will step in for his first start with the 49ers and his first since 2021. He has been with the team for the last two seasons.
Purdy has started all 10 games this season, amassing 2,613 passing yards, 13 touchdowns, and eight interceptions. His absence will be a significant setback for a 49ers team striving to turn their season around and get back in the NFC West race.
Defensive end Nick Bosa (hip/oblique) and cornerback Charvarius Ward have also been ruled out.
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