The San Francisco 49ers will host the Los Angeles Rams at Levi's Stadium in Santa Clara, California, on Thursday, December 12, with kickoff set for 5:15 p.m. PT. The 49ers enter the NFC West clash as 2.5-point favorites.

As part of the weekly NFL Pick 'em contest, 49ers Webzone staff members predict the winners of every NFL game. For Week 15, five of the seven participating staff members have picked the 49ers to defeat the Rams. Meanwhile, among the fans participating in the contest, 79 percent are also forecasting a 49ers victory.

Most One-Sided Matchup: Ravens at Giants


The most lopsided prediction for Week 15 involves Sunday's game between the Baltimore Ravens and the New York Giants. A staggering 99 percent of participants believe the Ravens will emerge victorious in what is widely viewed as a mismatch.

Most Competitive Matchup: Cowboys at Panthers


The tightest contest of the week appears to be Sunday's game between the Dallas Cowboys and the Carolina Panthers, with 62 percent of fans favoring the Cowboys to edge out a win.


Week 15 NFL Matchups


Below is a breakdown of all 16 matchups for the upcoming slate of NFL games.

Picks Away Home Picks
21%
Rams
49ers
79%
88%
Chiefs
Browns
12%
95%
Bengals
Titans
5%
84%
Commanders
Saints
16%
99%
Ravens
Giants
1%
62%
Cowboys
Panthers
38%
73%
Jets
Jaguars
27%
20%
Dolphins
Texans
80%
10%
Colts
Broncos
90%
27%
Bills
Lions
73%
26%
Steelers
Eagles
74%
8%
Patriots
Cardinals
92%
14%
Buccaneers
Chargers
86%
82%
Packers
Seahawks
18%
4%
Bears
Vikings
96%
87%
Falcons
Raiders
13%


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