Guerendo, a rookie, was thrust into the starting lineup after injuries depleted the 49ers' running back corps. He played through a foot sprain in Week 15 against the Los Angeles Rams but emerged from the game with a hamstring injury.
Meanwhile, Williams missed his fifth consecutive game due to an ankle injury. Head coach Kyle Shanahan acknowledged the possibility that the veteran offensive lineman could miss the remainder of the season.
Here are the latest in-game injury updates for the 49ers. This article will be updated as new injuries are reported.
LB Dre Greenlaw (calf, out)
Dre Greenlaw exited the game in the first quarter after suffering a right calf injury. The 49ers announced that the linebacker is questionable to return. Dee Winters replaced Greenlaw.
Update: The 49ers have ruled out Greenlaw.
DE Leonard Floyd (shoulder, returned)
Leonard Floyd exited the game in the first quarter due to a shoulder injury and is listed as questionable to return.
Update: Floyd briefly returned to the game in the second quarter but exited again after showing signs of discomfort. He later returned again.
T Jaylon Moore (quad, questionable)
Jaylon Moore stayed down on the field after a play in the third quarter but eventually managed to walk slowly to the sideline before heading to the medical tent for evaluation. The 49ers later announced that Moore is questionable to return due to a quad injury.
Guard Spencer Burford stepped in to replace Moore at left tackle.
G Aaron Banks (knee, out)
Aaron Banks was assisted off the field after sustaining an injury on a play in the fourth quarter. The 49ers quickly ruled him out with a knee injury. Nick Zakelj replaced Banks at left guard.
Related News
More San Francisco 49ers News
-
Packers reportedly signing 49ers guard Aaron Banks in free agency
NFL insider Ian Rapoport reports that the Green Bay Packers are set to sign free-agent guard Aaron Banks from the San Francisco 49ers, bringing his time in the Bay Area to an end. Rapoport adds that it's a four-year deal worth up to $77 million. Aaron Banks (6-5, 325) was... -
49ers tackle Jaylon Moore poised to cash in during free agency
Offensive tackle Jaylon Moore is one of several key San Francisco 49ers players set to hit free agency this week. Moore has primarily served as a backup, filling in when a starter was unavailable. He started five games last season in place of an injured Trent Williams but... -
Chiefs signing 49ers OT Jaylon Moore in free agency
NFL teams can officially begin negotiating with impending unrestricted free agents, and the Kansas City Chiefs wasted no time. According to Albert Breer of Sports Illustrated, they are signing San Francisco 49ers offensive tackle Jaylon Moore to a two-year, $30 million deal. He... -
Schefter: Dre Greenlaw and Talanoa Hufanga likely to leave 49ers
At the NFL Scouting Combine last week, San Francisco 49ers general manager John Lynch made it clear that the team would love to retain linebacker Dre Greenlaw in 2025. However, that would require signing him to a new deal. Greenlaw is set to become a free agent next week, and...