The San Francisco 49ers are set to host the Detroit Lions at Levi's Stadium in Santa Clara, California, on Monday, December 30, at 5:15 p.m. PT. The Lions enter the contest as 3.5-point favorites.

Each week, 49ers Webzone staff members participate in the NFL Pick 'em contest, predicting the winners of every game. For Week 17, none of the seven participating staff members have chosen the 49ers to upset the Lions.

Fan predictions echo that sentiment. As of this post, 81 percent of fans participating in the NFL Pick 'em contest have picked the Lions to emerge victorious.

Most One-Sided Matchup: Jets at Bills


The most lopsided prediction of the week comes from Sunday's matchup between the New York Jets and the Buffalo Bills. A unanimous 100 percent of participants expect the Bills to dominate and secure the win.


Most Competitive Matchup: Titans at Jaguars


In contrast, the tightest race in the predictions belongs to Sunday's game between the Tennessee Titans and the Jacksonville Jaguars. With 57 percent of participants picking the Jaguars.

Week 17 NFL Matchups


Below is a breakdown of the remaining 11 matchups for the upcoming slate of NFL games.

Picks Away Home Picks
98%
Chargers
Patriots
2%
94%
Colts
Giants
6%
0%
Jets
Bills
100%
38%
Raiders
Saints
62%
3%
Panthers
Buccaneers
97%
43%
Titans
Jaguars
57%
4%
Cowboys
Eagles
96%
78%
Dolphins
Browns
22%
35%
Packers
Vikings
65%
7%
Falcons
Commanders
93%
81%
Lions
49ers
19%


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