The Arizona Cardinals will host the San Francisco 49ers at State Farm Stadium in Glendale, Arizona, on Sunday, January 5, at 1:25 p.m. PT. The Cardinals are currently favored by 4.5 points.

Each week, 49ers Webzone staff members participate in the NFL Pick 'em contest, predicting the winners of every NFL game. For Week 18, only one of the four participating staff members has picked the 49ers to beat the Cardinals.

As of this post, 55 percent of fans participating in the NFL Pick 'em contest have predicted a Cardinals victory. This highlights the NFC West showdown as one of the more polarizing matchups of Week 18, with opinions divided on whether the 49ers can stage an upset.

Most One-Sided Matchups: Bears at Packers, Browns at Ravens


Among all Week 18 games, the matchups between the Chicago Bears and Green Bay Packers and the Cleveland Browns and Baltimore Ravens are the most one-sided. An overwhelming 100 percent of fans predict victories for the Packers and Ravens.


Most Competitive Matchup: Vikings at Lions


The most anticipated game of the weekend is Sunday's showdown between the Minnesota Vikings and Detroit Lions. The winner will secure the NFC's top seed and home-field advantage throughout the playoffs. Currently, 54 percent of fans predict the Lions will prevail, making this one of the most competitive matchups of Week 18.

Week 18 NFL Matchups


Below is a breakdown of all 16 matchups for the upcoming slate of NFL games.

Picks Away Home Picks
0%
Browns
Ravens
100%
78%
Bengals
Steelers
22%
13%
Panthers
Falcons
87%
89%
Commanders
Cowboys
11%
0%
Bears
Packers
100%
82%
Texans
Titans
18%
22%
Jaguars
Colts
78%
90%
Bills
Patriots
10%
10%
Giants
Eagles
90%
1%
Saints
Buccaneers
99%
39%
Chiefs
Broncos
61%
92%
Chargers
Raiders
8%
25%
Seahawks
Rams
75%
82%
Dolphins
Jets
18%
45%
49ers
Cardinals
55%
46%
Vikings
Lions
54%


Nobody's perfect. Did you find a mistake in this article?
Report it.


More San Francisco 49ers News