The game kicks off at 10:00 am and as usual, you can visit 49erswebzone.com for the latest news and updates during and after the game.
Within our NFL Pick 'em Contest, 35% of fans believe that the 49ers will win this game.
Within Sportstacular, a popular mobile phone scores app, 21% of fans believe that the 49ers will win this game.
You can follow the game live on NFL.com's Game Center.
You can also discuss the game with fans in the 49erswebzone.com forums.
More San Francisco 49ers News
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49ers host Rams in Week 15: Predictions favor San Francisco
The San Francisco 49ers will host the Los Angeles Rams at Levi's Stadium in Santa Clara, California, on Thursday, December 12, with kickoff set for 5:15 p.m. PT. The 49ers enter the NFC West clash as 2.5-point favorites. As part of the weekly NFL Pick 'em contest, 49ers... -
49ers mailbag: What do the 49ers have left in the tank for the last four games? Will SF bring back Robert Saleh? Can Brock Purdy beat good teams?
It's always a big week when the San Francisco 49ers play the Los Angeles Rams. In 2021, the rivalry became even bigger when the 49ers had to win in the season's final week, in Los Angeles, to make it into the playoffs. On Thursday night, the 49ers must win again to keep their... -
49ers vs. Rams injury updates: Ji'Ayir Brown questionable to return
The San Francisco 49ers entered Thursday night's NFC West showdown against the Los Angeles Rams without key players, most notably left tackle Trent Williams, who is sidelined for the fourth straight game with an ankle injury. On defense, standout rookie safety Malik Mustapha... -
Will the 49ers move on from Brock Purdy, Kyle Shanahan? One NFL insider believes they will not
"The season is lost, but the 49ers are still building around coach and QB." Those are the words of The Athletic's Dianna Russini in her latest NFL column, in which she writes that despite the San Francisco 49ers horrid season, the team is sticking to its plan of committing to...