The 49ers are coming off of a 16-6 loss to the Baltimore Ravens while the Rams are coming off of a 23-20 loss to the Arizona Cardinals.
The game kicks off at 1:15 PM and, as usual, you can visit 49erswebzone.com for the latest news and updates during and after the game.
The game will be televised on FOX.
In the 49erswebzone.com Pick 'Em Contest, 99% of 49ers fans believe that the 49ers will win this game.
Within Sportstacular, a popular mobile phone scores application, 94% of fans believe that the 49ers will win this game.
You can follow the game live on NFL.com's Game Center.
You can also discuss the game with fans in the 49erswebzone.com forums.
More San Francisco 49ers News
-
San Francisco 49ers' 2025 opponents finalized after clinching last-place schedule
The San Francisco 49ers' Week 17 loss to the Detroit Lions officially locked the team into last place in the NFC West, regardless of the outcome of their Week 18 matchup against the Arizona Cardinals. While the season has been disappointing, the silver lining is that the 49ers... -
49ers mailbag: Why did SF abandon the run against Detroit? Will the 49ers focus on offense or defense this offseason? Will SF replace Nick Sorensen with Robert Saleh?
There are a lot of questions that will follow the San Francisco 49ers into the offseason. Who will get extensions? Who will be let go? What moves will they make in free agency and the draft? And many more. You have questions, as well, and that's a good thing because we opened... -
49ers announce roster moves ahead of season finale in Arizona
On Saturday, the San Francisco 49ers announced the following roster moves ahead of the 2024 season finale against the Arizona Cardinals: Promoted DL Alex Barrett from the team's practice squad Promoted LB DeShaun White from the practice squad Elevated WR Trent Taylor from the... -
49ers TE George Kittle reaches milestone against Lions
San Francisco 49ers tight end George Kittle needed just 33 yards on Monday night to secure his fourth career season with at least 1,000 receiving yards. Kittle reached the milestone in the first quarter against the Detroit Lions, accomplishing it on the play shown...