Davis is still recovering from a concussion he suffered in Week 11 against the New York Giants. McDonald is recovering from a back injury.
Also ruled out is nose tackle Glenn Dorsey, who is still trying to comeback from a torn biceps muscle.
Cornerback Tramaine Brock (hamstring) and safety Bubba Ventrone (groin) are listed as questionable.
More San Francisco 49ers News
-
49ers vs. Rams final injury report: Williams among 3 ruled out for TNF; Guerendo, Bosa questionable
The San Francisco 49ers are preparing for their Week 15 contest against the Los Angeles Rams on Thursday at Levi's Stadium in Santa Clara, California. Both teams have released their official injury reports, which are provided below. San Francisco 49ers Out G Ben Bartch... -
Sidelined 49ers: Who's out against the Bears?
San Francisco 49ers cornerback Deommodore Lenoir is set to return for Sunday's game against the Chicago Bears after missing last week's matchup against the Buffalo Bills due to a knee injury. Safety Talanoa Hufanga, recently activated from injured reserve on Saturday, will also... -
Sidelined 49ers: Who's out against the Rams?
As the San Francisco 49ers prepare for their Thursday night NFC West showdown against the Los Angeles Rams, there remains uncertainty around linebacker Dre Greenlaw's status. While he is expected to play, the team has yet to announce whether he will be activated off the... -
49ers Notebook: 'We're going to find out who wants to be here'; Dre Greenlaw's return sparks team; Purdy's costly INT; Rams RB talks a little trash after win
Underneath the frustration of their rather awful 12-6 loss to the Los Angeles Rams on Thursday night, the San Francisco 49ers experienced one of the best moments of their forgettable 2024 season -- the return of linebacker Dre Greenlaw from the torn Achilles that kept him on...