Pro Football Talk is calling Davis' time off a retirement.
The 49ers have already gone through a coaching change, a number of free agent losses, and the retirements of linebackers Patrick Willis, Chris Borland and defensive lineman Justin Smith.
"After a few years of thought, I've decided it will be best for me to take a year or so away from the NFL. This will be a time for me to allow my Brain and Body a chance to heal. I know many won't understand my decision, that's ok," Davis said.
He added, "I hope you too have the courage to live your life how you planned it when day dreaming to yourself growing up. Your Life is Your dream and you have the power to control that dream. Im simply doing what's best for my body as well as my mental health at this time in my life."
Last season, Davis missed nine games due to injury, including a concussion which had lingering symptoms. In the seven games that he played, the 49ers offense averaged 173 rushing yards per game. In the nine games that he missed, they averaged just 107 yards per game.
Davis, who is just 25 years old, was the 11th overall selection by the 49ers in the 2010 NFL Draft.
General Manager Trent Baalke thanked Davis for his contributions and wished him "the best as he moves on from the game.
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