| 1st | 2nd | 3rd | 4th | Tot | |
| SF | 3 | 10 | 0 | 3 | 16 |
| BUF | 7 | 10 | 7 | 21 | 45 |
Kevin Hoffman-USA TODAY Sports
Following a back-and-forth first half, neither team would score again until late in the third quarter when Taylor would complete a 30-yard touchdown pass to WR Justin Hunter to give the Bills a 24-13 lead with just over 2 minutes remaining in the quarter.
The 49ers added a field goal to cut the Bills' lead to 8, but two fourth quarter scores would extend the Buffalo lead to 38-16. The first score was on an 18-yard run by McCoy and the second came on a touchdown reception by WR Robert Woods.
| Week | Running Back | Rush Yds | TDs |
| 1 | Todd Gurley, LA | 47 | 0 |
| 2 | Fozzy Whittaker, CAR | 100 | 0 |
| 3 | Christine Michael, SEA | 108 | 2 |
| 4 | Ezekiel Elliott, DAL | 138 | 1 |
| 5 | David Johnson, ARI | 157 | 2 |
| 6 | LeSean McCoy, BUF | 140 | 3 |
With about 7 minutes left in the fourth quarter and with a 49ers comeback well out of reach, Bills backup quarterback EJ Manuel, along with a number of other reserves, entered the game. The result was more of the same against the 49ers poor run defense. Bills RB Mike Gillislee pulled off an easy 44-yard touchdown run to give Buffalo a 45-16 lead. That's how the game ended as the Bills outscored the 49ers 28-3 in the second half and scored 21 in the fourth quarter alone.
| SF | BUF | |
| First Downs | 16 | 29 |
| Total Yards | 300 | 491 |
| Passing Yards | 167 | 179 |
| Rushing Yards | 133 | 312 |
| Penalties (Yds) | 6 (52) | 7 (71) |
| Turnovers | 1 | 2 |
| Punts (AVG) | 5 (35) | 3 (40) |
| Time of Pos. | 24:50 | 34:39 |
The 49ers defense has allowed a 100-yard rusher in each of their five-straight losses. During this blowout loss against the Bills, the 49ers defense gave up 140 rushing yards and three touchdowns to Buffalo running back McCoy. The 49ers defense gave up 312 yards on the ground to the Bills. Taylor, the Bills' starting quarterback, ended the game 17 of 26 for 179 yards passing and two touchdowns. Buffalo's 45 points were the most by the Bills since scoring 49 in a 2010 victory over the Cincinnati Bengals.
| 49ers Team Leaders | ||||
| Passing | CP/AT | YDS | TD | INT |
| C. Kaepernick | 13/29 | 187 | 1 | 0 |
| Rushing | CAR | YDS | TD | LG |
| C. Kaepernick | 8 | 66 | 0 | 29 |
| C. Hyde | 14 | 52 | 0 | 15 |
| Receiving | REC | YDS | TD | LG |
| Q. Patton | 4 | 52 | 0 | 17 |
| T. Smith | 3 | 76 | 1 | 53T |
Injuries
CB Rashard Robinson left the game in the third quarter with a concussion. He will enter the league's concussion protocol this week.
RB Carlos Hyde left the game in the third quarter with a possible shoulder injury. He was reportedly questionable to return, but did re-enter the game shortly following the injury.
Notes and Quotes
"I thought he was ok," head coach Chip Kelly said of Colin Kaepernick. "There are some positives that you can really build with him that I thought he did. I thought he extended some drives keeping plays alive with his legs."
"I think we need to run the ball as a group better," Kelly said.
"For his first game back, I think he did an OK job," Kelly said of Kaepernick. He didn't have an answer for the 49ers' continued woes against the run and said that they would have to review the game. "We didn't tackle well," Kelly said.
"I think we've got to do a better job as coaches to put our guys in position to make plays," Kelly said regarding the 49ers' poor run defense.
Kelly reiterated that Kaepernick's contract had nothing to do with the decision to start him against the Bills.
"I was very excited, very happy to be out there," said Kaepernick following the loss.
"I don't understand what's un-American about fighting for liberty and justice for everybody," said Kaepernick.
"It is embarrassing to have the ball run on you like that when you know they're going to run the ball," said S Eric Reid.
The 49ers' 16 points were their fewest scored of the season.
The 49ers have allowed an average of 430.8 total yards during their five-game losing streak.
The 49ers have allowed 1,046 rushing yards to opponents through six games. They are on pace to allow 2,789.
Postgame Video
Our own Al Sacco was at New Era Field to cover the game. Below are some postgame videos from the game.
Related News
More San Francisco 49ers News
-
Kyle Shanahan provides day-after injury updates following 49ers' Week 15 loss
San Francisco 49ers head coach Kyle Shanahan spoke to reporters via a conference call on Friday, the day after the team's Week 15 loss to the Los Angeles Rams. Among the key topics were updates on player injuries from the game. Safety Ji'Ayir Brown sustained a groin injury... -
Talanoa Hufanga delivers inspiring message to 49ers teammates after loss to Rams
The San Francisco 49ers' playoff hopes are all but dashed. Thursday night's 12-6 loss to the Los Angeles Rams dropped the team to 6-8, leaving a postseason berth unlikely. With three games remaining, the focus shifts to how the team will respond to adversity and finish the... -
What Kyle Shanahan, others said after 49ers' 12-6 loss vs. Rams
San Francisco 49ers head coach Kyle Shanahan and several others spoke with reporters after Thursday's 12-6 Week 15 loss to the Los Angeles Rams. Here is what they said. Transcripts provided by the San Francisco 49ers Communications staff. 49ers Head Coach Kyle... -
Dre Greenlaw exits with sore knee, plus other 49ers injury updates from loss to Rams
San Francisco 49ers head coach Kyle Shanahan shared several injury updates following Thursday night's disappointing loss to the Los Angeles Rams. Linebacker Dee Winters left the game with a neck injury and did not return. Safety Ji'Ayir Brown also exited in the second half...