49ers' 2021 schedule: Game-by-game look at their return to Super Bowl contention

The 49ers' season opens with road games against fellow last-place teams in Detroit and Philadelphia before a home opener against the Green Bay Packers, the.....

San Francisco 49ers

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SUN

5

jan

Sun, Jan 5 | 9:25 PM · State Farm Stadium, One Cardinals Drive, Glendale, AZ

49ers at Cardinals

✔ Arizona Cardinals - San Francisco 49ers

TUE

31

dec

Tue, Dec 31 | 1:15 AM · Levi's Stadium, 4900 Marie P DeBartolo Way, Santa Clara, CA

Lions at 49ers

✔ San Francisco 49ers - Detroit Lions

SUN

22

dec

Sun, Dec 22 | 9:25 PM · Hard Rock Stadium, 2269 Northwest 199th Street, Miami Gardens, FL

49ers at Dolphins

✔ Miami Dolphins - San Francisco 49ers

FRI

13

dec

Fri, Dec 13 | 1:15 AM · Levi's Stadium, 4900 Marie P DeBartolo Way, Santa Clara, CA

Rams at 49ers

✔ San Francisco 49ers - Los Angeles Rams

SUN

8

dec

Sun, Dec 8 | 9:25 PM · Levi's Stadium, 4900 Marie P DeBartolo Way, Santa Clara, CA

Bears at 49ers

✔ San Francisco 49ers - Chicago Bears

MON

2

dec

Mon, Dec 2 | 1:20 AM · Highmark Stadium, One Bills Drive, Orchard Park, NY

49ers at Bills

✔ Buffalo Bills - San Francisco 49ers

SUN

24

nov

Sun, Nov 24 | 9:25 PM · Lambeau Field, 1265 Lombardi Avenue, Green Bay, WI

49ers at Packers

✔ Green Bay Packers - San Francisco 49ers

SUN

17

nov

Sun, Nov 17 | 9:05 PM · Levi's Stadium, 4900 Marie P DeBartolo Way, Santa Clara, CA

Seahawks at 49ers

✔ San Francisco 49ers - Seattle Seahawks

SUN

10

nov

Sun, Nov 10 | 6:00 PM · Raymond James Stadium, 4201 North Dale Mabry Highway, Tampa, FL

49ers at Buccaneers

✔ Tampa Bay Buccaneers - San Francisco 49ers

MON

28

oct

Mon, Oct 28 | 12:20 AM · Levi's Stadium, 4900 Marie P DeBartolo Way, Santa Clara, CA

Cowboys at 49ers

✔ San Francisco 49ers - Dallas Cowboys

SUN

20

oct

Sun, Oct 20 | 8:25 PM · Levi's Stadium, 4900 Marie P DeBartolo Way, Santa Clara, CA

Chiefs at 49ers

✔ San Francisco 49ers - Kansas City Chiefs

FRI

11

oct

Fri, Oct 11 | 12:15 AM · Lumen Field, 800 Occidental Avenue South, Seattle, WA

49ers at Seahawks

✔ Seattle Seahawks - San Francisco 49ers

SUN

6

oct

Sun, Oct 6 | 8:05 PM · Levi's Stadium, 4900 Marie P DeBartolo Way, Santa Clara, CA

Cardinals at 49ers

✔ San Francisco 49ers - Arizona Cardinals