The San Francisco 49ers will travel internationally this week to face the NFC West rival Arizona Cardinals on ESPN's Monday Night Football, live from Estadio Azteca in Mexico City. This matchup is one of five NFL games to be played internationally this season and will mark the 62nd meeting all-time between the two teams, with San Francisco leading the series, 32- 29. This matchup is also a rematch of the first-ever regular season game played outside of the United States, when the Cardinals and 49ers squared off at Estadio Azteca in 2005.
The Niners are coming off their second straight win after beating the Los Angeles Chargers 22-16. The 49ers offense put up 387 total net yards, including 157 rushing yards on 41 carries. QB Jimmy Garoppolo completed 19 of his 28 passing attempts for 240 yards and registered a one-yard rushing touchdown. RB Christian McCaffrey registered 77 combined yards and scored his second rushing touchdown in three games with the team. WR Brandon Aiyuk caught six passes for a team-high 84 yards.
Defensively, the Niners held the Chargers scoreless in the second half and allowed just 51 total rushing yards. DL Nick Bosa, DL Charles Omenihu, and DL Jordan Willis each registered a sack on the night. S Talanoa Hufanga intercepted Chargers QB Justin Herbert once, giving him his fourth interception on the season. LB Dre Greenlaw and LB Fred Warner each registered a team-high seven tackles.
The 49ers Communications staff provided the above breakdown.
Below is everything you need to know to follow the upcoming game.
When does the game start?
Monday, November 21 at 5:15 p.m. PT
Where is the game being played?
Estadio Azteca in Mexico City, Mexico
Who are the head coaches?
49ers: Kyle Shanahan
Cardinals: Kliff Kingsbury
What channel is the game on?
Network: ESPN
Play-By-Play: Joe Buck
Color Analyst: Troy Aikman
Sideline Reporter: Lisa Salters
What areas will receive the broadcast?
The game will be nationally broadcast.
Where can I stream the game?
You can watch the matchup live on Watch ESPN or the ESPN app. Monday Night Football is also available to watch on the Yahoo Sports app and NFL app.
Where can I listen to the radio broadcast?
Bay Area fans can listen on KNBR 680 AM/104.5 FM and The Bone 107.7 FM, where Greg Papa and Tim Ryan will call the game.
Jesús Zárate and Mayra Gomez will call the game in Spanish. That broadcast can be listened to at 49ers.com/news/Espanol.
Arizona area fans can listen on Arizona Sports 98.7 FM, where Dave Pasch and Ron Wolfley will call the game.
Nationally, fans can listen to the game via Westwood One Sports, where Ryan Radtke and Mike Golic will call the game.
NFL+ subscribers can listen to the game through that service.
San Francisco: SiriusXM 81 or 226 and the SXM App
Arizona: SiriusXM 85 or 225 and the SXM App
National: SiriusXM 88 and the SXM App
Game discussion
Fans can discuss the game within our Niner Talk forum.
How has this series played out historically?
Matchups: 61
Series Record: 49ers lead series 32-29
49ers Home Record vs. Cardinals: 49ers lead series 18-14
49ers Away Record vs. Cardinals: Cardinals lead series 15-14
First Meeting: 11/18/51, Cardinals win 27-21, at SF*
Last Meeting: 11/7/21, Cardinals win 31-17, at SF
Current Streak: Lost 2
Longest 49ers Win Streak: 5 – 3 times (Last 9/13/09 – 11/20/11)
Longest Cardinals Win Streak: 8 – (9/27/15 – 10/28/18)
Most 49ers Points: 56 (10/18/92): 49ers win 56-17, at SF
Most Cardinals Points: 34 – 2 times, (Last 9/10/06): Cardinals win 34-27, at Arz.
49ers Shutouts: None
Cardinals Shutouts: None
*Chicago Cardinals
49ers Notes
- QB JIMMY GAROPPOLO completed 19 of 28 atts. (67.9 pct.) for 240 yards & 0 INTs in Week 10. Has 1,590 pass yards & 13 TDs vs. 3 INTs for a 112.7 rating in 5 career games vs. Az. Has a 100+ rating & 0 INTs in 4 of 5 career games on MNF. Aims for his 5th in a row vs. Az. with 2+ TD passes.
- RB CHRISTIAN MCCAFFREY had a rushing TD last week & aims for his 3rd in a row with SF with 75+ scrimmage yards & rush TD. Has 457 scrimmage yards (152.3 per game) & 2 TDs (1 rush, 1 rec.) in 3 career games vs. Az. Aims for his 3rd in row vs. Az. with 9+ catches & 4th in row vs. Az. with 100+ scrimmage yards.
- RB ELIJAH MITCHELL led the team with 89 rush yards last week. Has 80+ scrimmage yards in 6 of his past 7. Had 91 rush yards in only career MNF game (11/15/21 vs. LAR). WR DEEBO SAMUEL has 100+ scrimmage yards in 3 of his past 4 games on MNF. Aims for 3rd in a row on MNF with a TD. Has 5+ catches in 2 of his past 3 vs. Az.
- WR BRANDON AIYUK had 89 rec. yards & a TD catch in the last meeting. Aims for his 5th in a row with 6+ catches & 80+ rec. yards.
- TE GEORGE KITTLE has a rec. TD in 2 of his past 3 on MNF. Had 101 rec. yards & rec. TD in the last meeting. Aims for 3rd in a row vs. Az. with 90+ rec. yards.
- DE NICK BOSA had sack & 3 TFL last week. Leads NFC with 9.5 sacks & aims for 4th in a row with a sack. Has a FF in 2 of his past 3 vs. Az. & aims for his 3rd in a row vs. Az. with TFL. Has 5 sacks, 6 TFL, FF & FR in 4 career MNF games.
- LB FRED WARNER tied a career high with 3 PD in Week 10. Aims for his 7th in a row vs. Az. with 9+ tackles.
- S TALANOA HUFANGA has INT in 2 of his past 3. Aims for 3rd in a row on MNF with PD.