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49ers 2021 Schedule

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• Preseason
•  
   
  Kansas City Chiefs

  Saturday, August 14 at 5:30 PM
  KPIX5
  L

  16-19
•  
  at
  Los Angeles Chargers

  Sunday, August 22 at 4:30 PM
  KPIX5
  W

  15-10
•  
   
  Las Vegas Raiders

  Sunday, August 29 at 1:00 PM
  KPIX5
  W

  34-10
• Regular Season
• Week 1
  at
  Detroit Lions

  Sunday, September 12 at 10:00 AM
  FOX
  W

  41-33
• Week 2
  at
  Philadelphia Eagles

  Sunday, September 19 at 10:00 AM
  FOX
  W

  17-11
• Week 3
   
  Green Bay Packers

  Sunday, September 26 at 5:20 PM
  NBC
  L

  28-30
• Week 4
   
  Seattle Seahawks

  Sunday, October 3 at 1:05 PM
  FOX
  L

  21-28
• Week 5
  at
  Arizona Cardinals

  Sunday, October 10 at 1:25 PM
  FOX
  L

  10-17
• BYE
• Week 7
   
  Indianapolis Colts

  Sunday, October 24 at 5:20 PM
  NBC
  L

  18-30
• Week 8
  at
  Chicago Bears

  Sunday, October 31 at 10:00 AM
  FOX
  W

  33-22
• Week 9
   
  Arizona Cardinals

  Sunday, November 7 at 1:25 PM
  FOX
  L

  17-31
• Week 10
   
  Los Angeles Rams

  Monday, November 15 at 5:15 PM
  ESPN
  W

  31-10
• Week 11
  at
  Jacksonville Jaguars

  Sunday, November 21 at 10:00 AM
  FOX
  W

  30-10
• Week 12
   
  Minnesota Vikings

  Sunday, November 28 at 1:25 PM
  FOX
  W

  34-26
• Week 13
  at
  Seattle Seahawks

  Sunday, December 5 at 1:25 PM
  CBS
• Week 14
  at
  Cincinnati Bengals

  Sunday, December 12 at 1:25 PM
  CBS
• Week 15
   
  Atlanta Falcons

  Sunday, December 19 at 1:05 PM
  CBS
• Week 16
  at
  Tennessee Titans

  Thursday, December 23 at 5:20 PM
  NFLN
• Week 17
   
  Houston Texans

  Sunday, January 2 at 1:05 PM
  CBS
• Week 18
  at
  Los Angeles Rams

  Sunday, January 9 at 1:25 PM
  FOX

* All times Pacific