The San Francisco 49ers face the Arizona Cardinals in a divisional matchup at Levi's Stadium, marking the 66th meeting in a series that San Francisco leads 36-29 all-time. The 49ers aim for their fifth consecutive win in the series and hope to improve their home record to 21-14 against the Cardinals.
Previous game
The 49ers are coming off a 30-13 victory against the New England Patriots at home. The offense was led by RB Jordan Mason, who tallied 24 carries for 123 yards and one touchdown. QB Brock Purdy completed 15 of 27 passes for 288 yards, one touchdown, and one interception, while TE George Kittle contributed four receptions for 45 yards, including a 12-yard touchdown catch from Purdy.
Defensively, the Niners held the Patriots to just 73 rushing yards and recorded a season-high 6.0 sacks on QB Jacoby Brissett. LB Fred Warner led the defense with seven tackles, one pass defensed, and a 45-yard interception return for a touchdown. DL Kevin Givens posted three tackles and a career-high 2.5 sacks, while DL Maliek Collins added 1.5 sacks and a fumble recovery. DL Nick Bosa contributed five tackles and 1.0 sack, and rookie DL Evan Anderson, in his NFL debut, registered two tackles, a forced fumble, and 1.0 sack.
The 49ers Communications staff provided the above breakdown.
Below is everything you need to know to follow the upcoming game.
When does the game start?
Sunday, October 6 at 1:05 p.m. PT
Where is the game being played?
Levi's Stadium in Santa Clara, California
Who are the head coaches?
49ers: Kyle Shanahan
Cardinals: Jonathan Gannon
Betting Odds
As of October 2, the 49ers are favored by 7.5 points in this game, with an over/under set at 49.5 points.
What channel is the game on?
Network: FOX
Play-By-Play: Kevin Burkhardt
Color Analyst: Tom Brady
Sideline Reporter: Erin Andrews
Sideline Reporter: Tom Rinaldi
Viewers outside the broadcast area can watch the game via NFL Sunday Ticket on YouTube TV or YouTube Premium, but a subscription to the package is required.
What areas will receive the broadcast?
The broadcast will be viewable within the markets designated below for those without NFL Sunday Ticket.
Coverage map courtesy of 506sports.com
Where can I stream the game?
NFL Sunday Ticket subscribers can stream the game using the YouTube TV app. Those who purchased through YouTube Premium can watch via the YouTube app. Additionally, NFL+ subscribers can stream the game in its entirety once the matchup has been completed.
Bay Area fans can stream the game through the official 49ers app or at 49ers.com.
Where can I listen to the radio broadcast?
49ers Radio
Bay Area fans can listen on KGO 810 AM and The Bone 107.7 FM, where Greg Papa and Tim Ryan will call the game.
Jesu?s Za?rate and Carlos Yustis will call the game in Spanish. That broadcast can be heard at 49ers.com/news/Espanol.
Cardinals Radio
Arizona area fans can listen on Arizona Sports 98.7 FM, where Dave Pasch and Ron Wolfley will call the game.
National Radio
Fans can listen to the game via Sports USA Radio, where Larry Kahn and James White will call the game.
Streaming
NFL+ subscribers can listen to the game through that service.
Game discussion
Fans can discuss the game within our Niner Talk forum.
How has this series played out historically?
Matchups: 65
Series Record: 49ers lead series 36-29
49ers Home Record vs. Cardinals: 49ers lead series 20-14
49ers Away Record vs. Cardinals: Series is tied 16-15
First Meeting: 11/18/51, Cardinals win 27-21, at SF*
Last Meeting: 12/17/23, 49ers win 45-29, at Arz.
Current Streak: Won 4
Longest 49ers Win Streak: 5 – 3 times (Last 9/13/09 – 11/20/11)
Longest Cardinals Win Streak: 8 – (9/27/15 – 10/28/18)
Most 49ers Points: 56 (10/18/92): 49ers win 56-17, at SF
Most Cardinals Points: 34 – 2 times, (Last 9/10/06): Cardinals win 34-27, at Arz.
49ers Shutouts: None
Cardinals Shutouts: None
*Chicago Cardinals
49ers Notes
- QB Brock Purdy passed for 288 yards and a touchdown in Week 4 and currently ranks 2nd in the NFL with 1,130 passing yards this season. He aims for his fourth consecutive game with 285+ passing yards and tied his career-high with 4 touchdown passes in the last meeting. He also aims for his fourth straight start against Arizona with a 130+ passer rating.
- RB Jordan Mason posted a career-high 160 scrimmage yards (123 rushing, 37 receiving) and tied his career high with his third rushing touchdown of the season last week. He ranks 2nd in the NFL with 447 rushing yards and is the only player with three games of 100+ rushing yards and a rushing touchdown in 2024. He aims for his third consecutive home game with 120+ rushing yards and a touchdown.
- TE George Kittle recorded his second touchdown catch of the season last week and is looking for his third consecutive game with a receiving touchdown. He has 3 receiving touchdowns in his past 3 home games against Arizona.
- WR Deebo Samuel has recorded 70+ scrimmage yards in each of his 3 games in 2024.
- WR Jauan Jennings led the team with 88 receiving yards last week and ranks 4th in the NFL with 364 receiving yards this season. He aims for his third consecutive game with 85+ receiving yards.
- WR Brandon Aiyuk aims for his fourth straight game with 40+ receiving yards. He had 6 catches for 148 yards in his last home meeting and is aiming for his fourth straight home game against Arizona with 50+ receiving yards.
- LB Fred Warner recorded his 10th career interception and 2nd career interception return for a touchdown last week. Since 2018, he leads all linebackers with 50 passes defensed and is one of five linebackers with 10+ interceptions. He has 109 tackles (9.1 per game) in 12 games against Arizona.
- DL Nick Bosa recorded his third sack of the season, his 11th career forced fumble, and his 4th career fumble recovery last week. He aims for his fourth consecutive game with a tackle for loss and has recorded a TFL in 5 of his last 6 games against Arizona.
- DL Maliek Collins aims for his third consecutive game with a sack.
- DL Leonard Floyd forced his fifth career fumble last week.
- DL Kevin Givens posted a career-high 2.5 sacks in Week 4.
- CB Charvarius Ward is one of five NFC defensive backs with a pass defensed in each of the first 4 weeks.
Cardinals Notes
- QB Kyler Murray had a touchdown pass and a 104.7 passer rating in Week 4. He is one of two NFC quarterbacks (alongside Dak Prescott) with three games in 2024 featuring a touchdown pass and no interceptions. He aims for his fourth consecutive road game with a 90+ rating and his third straight game at San Francisco with both a touchdown pass and a rushing touchdown.
- RB James Conner recorded 113 scrimmage yards (104 rushing, 9 receiving) and his third rushing touchdown of the season last week. He has scored a touchdown in 8 of his last 9 games and aims for his fifth straight road game with a touchdown. Conner has 6 touchdowns (5 rushing, 1 receiving) in his past 5 games against San Francisco.
- RB Trey Benson (rookie) had a career-high 50 rushing yards last week.
- WR Marvin Harrison Jr. (rookie) is one of two players (along with Justin Jefferson) with 4 receiving touchdowns this season and aims for his fourth straight game with a touchdown catch.
- WR Michael Wilson had 7 catches for 76 yards and 2 receiving touchdowns in his last road meeting. He aims for his third consecutive road game with a touchdown catch.
- WR Greg Dortch aims for his third straight road game with 6+ catches.
- TE Trey McBride has recorded 5+ catches in 2 of his 3 games this season and aims for his sixth consecutive road game with 5+ receptions. He tied his career high with 10 catches and had 102 receiving yards in his last meeting.
- S Budda Baker led the team with 14 tackles last week, marking his fifth career game with 14+ tackles. He ranks 2nd among defensive backs with 39 tackles in 2024. He aims for his third consecutive road game with a tackle for loss and his 11th straight game against San Francisco with 5+ tackles.
- S Jalen Thompson aims for his third consecutive game with 9+ tackles. He has recorded 5+ tackles in 5 of his last 6 road games.
- LB Mack Wilson has 6+ tackles in 3 of his 4 games this season.
- LB Dennis Gardeck had a sack in his last road meeting.
- LB Kyzir White aims for his fifth straight game with 7+ tackles.
- LB Zaven Collins has recorded a tackle for loss in 4 of his last 5 games.
