The Seattle Seahawks will host the San Francisco 49ers at Lumen Field in Seattle, Washington, on Thursday, October 10, at 5:15 p.m. PT. The 49ers are currently favored by 3.5 points.
Each week, 49ers Webzone staff members participate in the NFL Pick 'em contest, predicting the winners of every NFL game. For Week 6, all six participating staff members have picked the 49ers to beat the Seahawks.
Among fans participating in our NFL Pick 'em contest, 83 percent have predicted a 49ers victory, as of this post.
Most One-Sided Matchup: Browns at Eagles
The most lopsided prediction this week is for Sunday's matchup between the Cleveland Browns and the Philadelphia Eagles, with 97 percent expecting an Eagles win.
Most Competitive Matchup: Colts at Titans
The tightest prediction is for Sunday's game between the Indianapolis Colts and the Tennessee Titans, with 59 percent favoring the Colts to prevail.
Week 6 NFL Matchups
Below is a breakdown of all 14 matchups for this week's slate of NFL games.
| Picks | Away | Home | Picks |
|---|---|---|---|
|
83%
|
49ers
|
Seahawks
|
17%
|
|
28%
|
Jaguars
|
Bears
|
72%
|
|
8%
|
Cardinals
|
Packers
|
92%
|
|
59%
|
Colts
|
Titans
|
41%
|
|
96%
|
Texans
|
Patriots
|
4%
|
|
69%
|
Buccaneers
|
Saints
|
31%
|
|
3%
|
Browns
|
Eagles
|
97%
|
|
12%
|
Commanders
|
Ravens
|
88%
|
|
65%
|
Chargers
|
Broncos
|
35%
|
|
80%
|
Steelers
|
Raiders
|
20%
|
|
80%
|
Lions
|
Cowboys
|
20%
|
|
91%
|
Falcons
|
Panthers
|
9%
|
|
84%
|
Bengals
|
Giants
|
16%
|
|
84%
|
Bills
|
Jets
|
16%
|
