Below are the latest in-game injury updates for the 49ers.
RB Christian McCaffrey (knee, out)
The 49ers announced that running back Christian McCaffrey is questionable to return after suffering a knee injury. McCaffrey left the game in the second quarter, was evaluated in the medical tent, and then headed to the locker room.
Update: During a televised interview at the start of the second half, head coach Kyle Shanahan announced that McCaffrey would not return to the game.
The injury occurred in the play below. McCaffrey missed the first eight games of the season with Achilles tendinitis.
#49ers RB Christian McCaffrey is now going to the locker room.
The 49ers announced that defensive lineman Kevin Givens, who returned from a groin injury, is now questionable to return to the game after sustaining a chest injury.
Update: The 49ers have ruled Givens out.
LB Fred Warner (cramps, questionable)
Linebacker Fred Warner experienced cramping and was announced as questionable to return.
Update: Warner returned to the game.
RB Jordan Mason (head, returned)
Jordan Mason was evaluated for a concussion and cleared to return.
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