The San Francisco 49ers entered Sunday's matchup against the Miami Dolphins without two key offensive contributors: running back Isaac Guerendo and left tackle Trent Williams.
Guerendo, a rookie, was thrust into the starting lineup after injuries depleted the 49ers' running back corps. He played through a foot sprain in Week 15 against the Los Angeles Rams but emerged from the game with a hamstring injury.
Meanwhile, Williams missed his fifth consecutive game due to an ankle injury. Head coach Kyle Shanahan acknowledged the possibility that the veteran offensive lineman could miss the remainder of the season.
Here are the latest in-game injury updates for the 49ers. This article will be updated as new injuries are reported.
LB Dre Greenlaw (calf, out)
Dre Greenlaw exited the game in the first quarter after suffering a right calf injury. The 49ers announced that the linebacker is questionable to return. Dee Winters replaced Greenlaw.
Update: The 49ers have ruled out Greenlaw.
DE Leonard Floyd (shoulder, returned)
Leonard Floyd exited the game in the first quarter due to a shoulder injury and is listed as questionable to return.
Update: Floyd briefly returned to the game in the second quarter but exited again after showing signs of discomfort. He later returned again.
T Jaylon Moore (quad, questionable)
Jaylon Moore stayed down on the field after a play in the third quarter but eventually managed to walk slowly to the sideline before heading to the medical tent for evaluation. The 49ers later announced that Moore is questionable to return due to a quad injury.
Guard Spencer Burford stepped in to replace Moore at left tackle.
G Aaron Banks (knee, out)
Aaron Banks was assisted off the field after sustaining an injury on a play in the fourth quarter. The 49ers quickly ruled him out with a knee injury. Nick Zakelj replaced Banks at left guard.