OFFENSE:
QB(2): 5 Trey Lance(2024), & 14 Sam Darnold(2023)
RB(4): 23 Christia McCaffrey(2025), 25 Elijah Mitchell(2024), 24 Jordan Mason(2024), & 32 Tyrion Davis-Price(2025)
FB(1): 44 Kyle Juszczyk(2025)
WR(6): 19 Deebo Samuel(2025), 11 Brandon Aiyuk(2024), 15 Jauan Jennings(2023), 3 Ray-Ray McCloud III(2023), 6 Danny Gray(2025), & -- Ronnie Bell(2026)
TE(3): 85 George Kittle(2025), -- Cameron Latu(2026), & -- Brayden Willis(2026)
C(2): 64 Jake Brendel(2026), & 55 Jon Feliciano(2023)
LG(2): 65 Aaron Banks(2024), & 63 Nick Zakelj(2025)
RG(2): 74 Spencer Burford(2025), & 51 Jason Poe(2023)
LT(2): 71 Trent Williams(2026), & 75 Matt Pryor(2023)
RT(1): 68 Colton McKivitz(2024)
DEFENSE:
DE(5): 97 Nick Bosa(2023), 95 Drake Jackson(2025), 94 Clelin Ferrell(2023), 56 Austin Bryant(2023), & -- Robert Beal Jr.(2026)
DT(3): 91 Arik Armstead(2024), 99 Javon Kinlaw(2023), & 90 Kevin Givens(2023)
NT(2): 98 Javon Hargrave(2026), & 93 Kalia Davis(2025)
WLB(1): 57 Dre Greenlaw(2024)
MLB(2): 54 Fred Warner(2026), & 48 Oren Burks(2023)
SLB(2): -- Dee Winters(2026), & 40 Marcelino McCrary-Ball(2023)
CB(5): 7 Charvarius Ward(2024), 2 Deommodore Lenoir(2024), 22 Isaiah Oliver(2024), 26 Samuel Womack III(2025), & -- Darrell Luter Jr.(2026)
FS(3): 31 Tashaun Gipson Sr.(2023), 38 Myles Hartsfield(2023), & -- Ji'Ayir Brown(2026)
SS(2): 29 Talanoa Hufanga(2024), & 30 George Odum(2024)
SPECIAL TEAMS:
PK(1): -- Jake Moody(2026)
P(1): 18 Mitch Wishnowsky(2026)
LS(1): 46 Taybor Pepper(2025)
PRACTICE SQUAD:
- QB UDFA
- RB – Khalan Laborn
- FB – Jack Colletto
- WR 17 Chris Conley*
- WR 86 Tay Martin
- TE 82 Ross Dwelley*
- C – Corey Luciano
- RT 77 Alfredo Gutierrez**
- OT – Joey Fisher
- OL – Ilm Manning
- DE 58 Alex Barrett
- DE 92 Kerry Hyder Jr.*
- DT 96 T.Y. McGill Jr.*
- SLB – Jalen Graham
- CB 43 Qwuantrezz Knight
- CB – D'Shawn Jamison
- FS – Avery Young
PUP:
QB 13 Brock Purdy(2025)